CST, 13243T, Kinectin 1 (D5F7J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying KTN1. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, Kinectin 1 (D5F7J) Rabbit Monoclonal Antibody (CST #13243) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Immunofluorescence (Immunocytochemistry): 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity Kinectin 1 (D5F7J) Rabbit Monoclonal Antibody recognizes endogenous levels of total kinectin 1 protein. Species Reactivity: Human, Monkey, Dog Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val186 of human kinectin 1 protein. Background Kinectin 1 (KTN1) is an endoplasmic reticulum (ER)-enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1). Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking (2). The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly (3). Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER (4,5). Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer (6), hepatocellular carcinoma (HCC) (7), Parkinson's disease (8), and the autoimmune syndrome Behçet's disease (BD) (9,10). Alternate Names CG-1 antigen; CG1; KIAA0004; Kinectin; kinectin 1; kinectin 1 (kinesin receptor); Kinesin receptor; KNT; KTN1; MGC133337; MU-RMS-40.19 Specification REACTIVITY: H Mk Dg SENSITIVITY: Endogenous MW (kDa): 160 Source/Isotype: Rabbit IgG