CST, 14210S, SGLT2 Antibody

Polyclonal Antibody for studying SGLT2/SLC5A2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, SGLT2 Antibody (CST #14210) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity SGLT2 Antibody recognizes endogenous levels of total SGLT2 protein. This antibody does not recognize SGLT1 protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human SGLT2 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Na(+)/glucose cotransporter 2 (SGLT2) is one of the two main glucose transporters in the kidney proximal convoluted tubule. It is activated by Protein Kinase A and Protein Kinase C, likely through phosphorylation of Ser624 (1,2). SGLT2 is responsible for the majority of glucose reabsorption in the kidney (3,4), and mutations in SGLT2 are known to cause familial renal glucosuria (5,6). SGLT2 is a therapeutic target for type 2 diabetes. Inhibitors of SGLT2 have been developed in order to treat people with type 2 diabetes (7). Alternate Names Low affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 2; SC5A2; SGLT2; SLC5A2; Sodium/glucose cotransporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 2; solute carrier family 5 (sodium/glucose transporter), member 2; Solute carrier family 5 member 2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 46-75 SOURCE: Rabbit