CST, 14316T, C-Reactive Protein (D1N1U) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CRP. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, C-Reactive Protein (D1N1U) Rabbit Monoclonal Antibody (CST #14316) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10mM sodium HEPES (pH 7.5), 150mM NaCl, 100 μg/ml, 50% glycerol and less than 0.02% sodium azide. Store at -20ºC. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity C-Reactive Protein (D1N1U) Rabbit Monoclonal Antibody recognizes endogenous levels of total human C-reactive protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val38 of human C-reactive protein. Background C-reactive protein (CRP) is a pentraxin family protein involved in several host defense-related functions as a result of its ability to bind to foreign pathogens and damaged host cells (1). CRP is a cyclic, non-covalent pentameric protein and normal constituent of human sera that is produced primarily by hepatocytes (2). Secretion of CRP is induced by proinflammatory cytokines, including IL-6 and IL-1β, and significantly increases during acute phase responses to tissue injury, infection, or other inflammatory stimuli (3,4). The presence of CRP is often utilized as an inflammation marker, and monitoring CRP levels in plasma is a useful tool in assessing disease progression or treatment effectiveness. CRP is also regarded as a risk assessment factor for the development and progression of cardiovascular disease (5). CRP binds to phosphorylcholine that is present on the surface of damaged tissues and in the bacterial cell wall of certain pathogens (6). Through this calcium-dependent interaction, CRP promotes agglutination and initiates the activation of the complement cascade. This results in enhanced opsonization through CRP interaction with FcγRI and FcγRIIA, which facilitates phagocytosis (7). Alternate Names C Reactive Protein; C-reactive protein; C-reactive protein, pentraxin-related; C-reactive protein(1-205); CRP; MGC149895; MGC88244; pentraxin 1; PTX1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 25 Source/Isotype: Rabbit IgG