CST, 14380T, Pan Na Channel alpha Subunit (D2I9C) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SCN5A/SCN4A/SCN10A/SCN8A/SCN2A/SCN1A/SCN7A/SCN11A/SCN9A. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Pan Na Channel alpha Subunit (D2I9C) Rabbit Monoclonal Antibody (CST #14380) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Pan Na Channel alpha Subunit (D2I9C) Rabbit Monoclonal Antibody recognizes endogenous levels of Na channel α subunits. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to cytoplasmic residues between repeats of III and IV of all human Na channel α subunits. Background Voltage gated sodium channels are composed of a large alpha subunit and auxiliary beta subunits. The alpha subunit has 4 homologous domains, with each domain containing 6 transmembrane segments. These segments function as the voltage sensor and sodium permeable pore. Upon change of membrane potential, the sodium channel is activated, which allows sodium ions to flow through (1,2). When associated with beta subunits or other accessory proteins, the alpha subunit is regulated at the level of cell surface expression, kinetics, and voltage dependence (3,4). There are 9 mammalian alpha subunits, named Nav1.1-Nav1.9 (5). These alpha subunits differ in tissue specificity and biophysical functions (6,7). Seven of these subunits are essential for the initiation and propagation of action potentials in the central and peripheral nervous system while Nav1.4 and Nav1.5 are mainly expressed in skeletal muscle and cardiac muscle (8,9). Mutations in these alpha channel subunits have been identified in patients with epilepsy, seizure, ataxia, sensitivity to pain, and cardiomyopathy (reviewed in 10). Alternate Names BFIC3; BFIS3; BFIS5; BFNIS; cardiac sodium channel alpha subunit; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2; CerIII; CIAT; CMD1E; CMPD2; CMS16; CTC-264K15.6; EA9; EIEE11; EIEE13; EIEE6; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FHM3; GEFSP2; GEFSP7; HB1; HB2; HBA; HBBD; HBSC II; HBSCI; HBSCII; HH1; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; HOKPP2; hPN3; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; LQT3; MED; motor endplate disease; MYOCL2; Na(v)1.2; Na(V)1.4; NAC1; NAC1A; NAC2; NaCh6; NaG; NaN; Nav1.1; Nav1.2; Nav1.4; Nav1.5; Nav1.6; Nav1.7; Nav1.8; NAV1.9; Nav2.1; Nav2.2; NE-NA; NENA; Neuroendocrine sodium channel; Peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; Peripheral sodium channel 1; PFHB1; PN1; PN3; PN4; PN5; Putative voltage-gated sodium channel subunit alpha Nax; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN4A; SCN5A; SCN6A; SCN7A; SCN8A; SCN9A; SCNAA; SCNBA; Sensory neuron sodium channel 2; SFNP; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; SkM1; SMEI; SNS; SNS-2; SNS2; Sodium channel protein brain I subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type 10 subunit alpha; Sodium channel protein type 11 subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type 7 subunit alpha; Sodium channel protein type 8 subunit alpha; Sodium channel protein type 9 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein type II subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel protein type IX subunit alpha; sodium channel protein type V alpha subunit; Sodium channel protein type V subunit alpha; Sodium channel protein type VII subunit alpha; Sodium channel protein type VIII subunit alpha; Sodium channel protein type X subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain type 2 alpha subunit; sodium channel voltage gated type 1 alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha subunit; sodium channel, voltage-gated, type IV, alpha subunit; sodium channel, voltage-gated, type IX, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage-gated, type V, alpha subunit; sodium channel, voltage-gated, type VI, alpha polypeptide; sodium channel, voltage-gated, type VII, alpha; sodium channel, voltage-gated, type VII, alpha polypeptide; sodium channel, voltage-gated, type VII, alpha subunit; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; sodium voltage-gated channel alpha subunit 1; sodium voltage-gated channel alpha subunit 10; sodium voltage-gated channel alpha subunit 11; sodium voltage-gated channel alpha subunit 2; sodium voltage-gated channel alpha subunit 4; sodium voltage-gated channel alpha subunit 5; sodium voltage-gated channel alpha subunit 7; sodium voltage-gated channel alpha subunit 8; sodium voltage-gated channel alpha subunit 9; SSS1; VF1; voltage-dependent sodium channel alpha subunit; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel Nav1.9; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subunit alpha Nav1.1; Voltage-gated sodium channel subunit alpha Nav1.2; Voltage-gated sodium channel subunit alpha Nav1.4; Voltage-gated sodium channel subunit alpha Nav1.5; Voltage-gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.7; Voltage-gated sodium channel subunit alpha Nav1.8; Voltage-gated sodium channel subunit alpha Nav1.9; voltage-gated sodium channel type II alpha subunit; voltage-gated sodium channel type VIII alpha protein Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 230-260 Source/Isotype: Rabbit IgG