CST, 14669T, HSD17B6 (D1T5H) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying HSD17B6. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, HSD17B6 (D1T5H) Rabbit Monoclonal Antibody (CST #14669) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity HSD17B6 (D1T5H) Rabbit Monoclonal Antibody recognizes endogenous levels of total HSD17B6 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu220 of human HSD17B6 protein. Background The type 6 17-β-hydroxysteroid dehydrogenase (HSD17B6, 17-β-HSD 6) regulates cellular hydroxysteroids by catalyzing the conversion of androsterone to epiandrosterone (1). This enzyme displays both oxidoreductase and epimerase activities, and is also known as 3(α->β)-hydroxysteroid epimerase. The interaction between HSD17B6 and hydroxysteroid compounds has an important effect on steroid activity as these compounds typically act in a stereo-specificity manner (1). Research studies show that the transcriptional activity of androgen receptor in prostate cell lines treated by androstanediol correlates with HSD17B6 protein level, which suggests an important role for enzyme in prostate cancer growth (2). Alternate Names 17-beta-HSD 6; 17-beta-HSD6; 17-beta-hydroxysteroid dehydrogenase type 6; 17-beta-hydroxysteroid dehydrogenase type 6 variant 1; 17-beta-hydroxysteroid dehydrogenase type 6 variant 2; 17-beta-hydroxysteroid dehydrogenase type 6 variant 3; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; 3-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; H17B6; HSD17B6; HSE; hydroxysteroid (17-beta) dehydrogenase 6 homolog; hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); hydroxysteroid 17-beta dehydrogenase 6; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase; Oxidative 3-alpha hydroxysteroid dehydrogenase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; oxidoreductase; retinol dehydrogenase; RODH; SDR9C6; Short chain dehydrogenase/reductase family 9C member 6; short chain dehydrogenase/reductase family 9C, member 6 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 29 Source/Isotype: Rabbit IgG