CST, 15160T, VIMP (D1D1M) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SELS. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, VIMP (D1D1M) Rabbit Monoclonal Antibody (CST #15160) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity VIMP (D1D1M) Rabbit Monoclonal Antibody recognizes endogenous levels of total VIMP protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys150 of human VIMP protein. Background VCP-interacting membrane protein (VIMP, selenoprotein S) is a putative reductase and endoplasmic reticulum (ER)-resident protein involved in the ER-associated degradation (ERAD) pathway (1,2). Research studies indicate that VIMP may play a protective role against inflammation and reduce ER-stress (3). The VIMP protein is a single-pass, transmembrane protein that recruits the cytosolic p97/VCP AAA-ATPase and its cofactors, UFD1 and NPL4, to the ER membrane (4). An ER membrane complex containing Derlin-1 and VIMP forms a critical node in the ERAD machinery and links substrate recognition in the ER lumen with the retrotranslocation function of the p97/VCP AAA-ATPase in the cytosol (1,4). Polymorphisms in the corresponding gene are associated with spontaneous preterm births and cardiovascular disease risk (5,6) while other studies do not support a correspondence between polymorphisms and inflammatory disorders (7). Alternate Names AD-015; ADO15; MGC104346; MGC2553; SBBI8; Selenoprotein S; SELENOS; SELS; SEPS1; tanis; valosin-containing protein-interacting membrane protein; VCP interacting membrane selenoprotein; VCP-interacting membrane protein; VIMP Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 21 Source/Isotype: Rabbit IgG