CST, 15849T, Olig1 (E3T6D) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying OLIG1 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin),Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, Olig1 (E3T6D) Rabbit Monoclonal Antibody (CST #15849) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:125 - 1:500 Immunofluorescence (Frozen): 1:400 - 1:800 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 35676 . Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin), Immunofluorescence (Frozen) Specificity / Sensitivity Olig1 (E3T6D) Rabbit Monoclonal Antibody recognizes endogenous levels of total Olig1 protein. Non-specific plasma membrane staining was observed in a mouse model of B cell lymphoma and spotty cytoplasmic staining of late spermatids was observed in mouse testis by immunohistochemistry. Species Reactivity: Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val26 of mouse Olig1 protein. Background Oligodendrocyte transcription factor 1 (Olig1) is a basic helix-loop-helix (bHLH) transcription factor expressed in developing and mature oligodendrocytes. Olig1 is involved in oligodendrocyte Specification, differentiation, and myelination and plays a crucial role in promoting the commitment of oligodendrocyte progenitor cells (1). Olig1 has also been shown to play an important role in remyelination after injury (2). Because of its role in development and myelination, Olig1 may play a role in neurodevelopmental disorders like Down syndrome and autism spectrum disorder and myelinating diseases like multiple sclerosis (3,4). Alternate Names AI836478; AW494459; Bhlhb; Bhlhb6; bHLHe2; bHLHe21; Olg; Olg-1; Olig1; Oligo1; Oligodendrocyte transcription factor 1; Oligodendrocyte-specific bHLH transcription factor 1; OTTMUSP00000021401 Specification REACTIVITY: M R SENSITIVITY: Endogenous MW (kDa): 27 Source/Isotype: Rabbit IgG