CST, 15910S, Eosinophil cationic protein (E6U5M) Rabbit Monoclonal Antibody (Alexa Fluor® 647 Conjugate)

Monoclonal Antibody for studying RNASE3. Validated for Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, Eosinophil cationic protein (E6U5M) Rabbit Monoclonal Antibody (Alexa Fluor^® 647 Conjugate) (CST #15910) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:100 - 1:400 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity Eosinophil cationic protein (E6U5M) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly130 of human Eosinophil cationic protein. Background Eosinophil cationic protein (ECP, RNASE3) is a member of the ribonuclease superfamily which has both cytotoxic and noncytotoxic properties (1-4). ECP is primarily produced and stored in the secondary granules of eosinophils, where it is involved in host defense against parasites, bacteria, and viruses (1-4). It has also been detected in the primary granules of circulating neutrophils, and can be synthesized by stimulated neutrophils (3,4). ECP is often used as a marker for eosinophilic disease and is measurable in samples such as serum, bronchoalveolar lavage, and nasal secretions (4). A large number of clinical studies are focused on the role of ECP in eosinophil-related disorders, particularly in asthma (5). Alternate Names cytotoxic ribonuclease; ECP; Eosinophil cationic protein; RAF1; Ribonuclease 3; ribonuclease A family member 3; ribonuclease, RNase A family, 3; ribonuclease, RNase A family, 3 (eosinophil cationic protein); RNase 3; RNASE3; RNS3 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG