CST, 15986T, PRSS8 (F2Z4K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PRSS8. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PRSS8 (F2Z4K) Rabbit Monoclonal Antibody (CST #15986) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity PRSS8 (F2Z4K) Rabbit Monoclonal Antibody recognizes endogenous levels of total PRSS8 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val98 of human PRSS8 protein. Background Prostasin (PRSS8), also known as channel activating protease 1 (CAP1), is a glycosylphosphatidylinositol (GPI)-anchored serine protease that is ubiquitously expressed in many tissues, including the small intestine, colon, esophagus, stomach, lung, skin, liver, prostate, kidney, and gallbladder (1). It acts as a proteolytic activator of the epithelial sodium channel and plays a major role in regulating sodium balance and glucose homeostasis (1,2). Aberrant PRSS8 expression has been associated with multiple cancers, including ovarian, prostate, breast, bladder, and gastric cancers (1). PRSS8 has been identified as a potential biomarker for early detection of ovarian cancer and, more recently, for Alzheimer's disease (2,3). Alternate Names CAP1; channel-activating protease 1; Prostasin; Prostasin heavy chain; Prostasin light chain; protease, serine 8; protease, serine, 8; PRSS8; Serine protease 8 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 36 Source/Isotype: Rabbit IgG