CST, 16453S, SLFN11 (D8W1B) Rabbit Monoclonal Antibody (PE Conjugate)

Monoclonal Antibody for studying SLFN11. Validated for Flow Cytometry (Fixed/Permeabilized). Highly specific and rigorously validated in-house, SLFN11 (D8W1B) Rabbit Monoclonal Antibody (PE Conjugate) (CST #16453) is ready to ship. Product Usage Information Flow Cytometry (Fixed/Permeabilized): 1:50 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Flow Cytometry (Fixed/Permeabilized) Specificity / Sensitivity SLFN11 (D8W1B) Rabbit Monoclonal Antibody (PE Conjugate) recognizes endogenous levels of total SLFN11 protein. Non-specific staining was observed in skeletal muscle. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human SLFN11 protein. Background SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition (1,2). Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents (1,3). Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication, leading to cell death (4). SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies (5). Alternate Names FLJ34922; Schlafen family member 11; SLFN11; SLFN8/9; SLN11 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG