CST, 18593T, OMG (F8B7X) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying OMG. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, OMG (F8B7X) Rabbit Monoclonal Antibody (CST #18593) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:400 - 1:1600 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity OMG (F8B7X) Rabbit Monoclonal Antibody recognizes endogenous levels of total OMG protein. This antibody detects a 70 kDa protein of unknown identity in some cell lines. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human OMG protein. Background Oligodendrocyte-myelin glycoprotein (OMG or OMgp) is a glycosylphosphatidylinositol (GPI)-linked membrane protein expressed in oligodendrocytes and myelin in the central nervous system (CNS) (1,2). OMG is a potent inhibitor of neurite outgrowth expressed in the late stages of myelination (3,4). It has been shown that this inhibitory effect occurs through interaction with Nogo receptor (NgR) and its associated complex; thus, disruption of this interaction may be a target for axonal recovery after injury (5). Altered levels of OMG protein have been seen in cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer's disease, implicating OMG in neurodegenerative diseases (6,7). OMG has also been implicated as a potential autoantigen in CNS inflammatory diseases such as acute disseminated encephalomyelitis and multiple sclerosis (8). Alternate Names oligodendrocyte myelin glycoprotein; Oligodendrocyte-myelin glycoprotein; OMG; OMGP Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 70-140 Source/Isotype: Rabbit IgG