CST, 19346S, PCSK7 (D4I5G) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PCSK7. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, PCSK7 (D4I5G) Rabbit Monoclonal Antibody (CST #19346) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity PCSK7 (D4I5G) Rabbit Monoclonal Antibody recognizes endogenous levels of total PCSK7 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu630 of human PCSK7 protein. Background PCSK7 (PC7) is a member of the subtilisin-like proprotein convertase family (1,2). Like other members of the family, the protein cleaves precursors at basic amino acids within the motif Arg/Lys-Xn-Arg (cleavage site) (n=2 or 4). PC7 was reported to be localized in the trans-golgi network and at the cell surface membrane, as well as in membrane internalized recycling vesicles (2,3). One function of PCSK7 is its critical role in growth factors processing, for example proEGF to EGF, proVEGF-C to VEGF-C, and BDNF neuropeptide maturation. PCSK7 is also involved in transferrin receptor shedding to regulate ion homeostasis (7,8) and MHC class I stability to regulate antigen presentation in the immunoresponse process (9). Alternate Names FLJ23503; FLJ45329; hPC8; LPC; Lymphoma proprotein convertase; PC7; PC8; PCSK7; Prohormone convertase 7; prohormone convertase 8, subtilisin-like; prohormone convertase PC7; Proprotein convertase 7; Proprotein convertase 8; proprotein convertase PC7; Proprotein convertase subtilisin/kexin type 7; proprotein convertase subtilisin/kexin type 7 precursor variant 2; SPC7; Subtilisin/kexin-like protease PC7 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 92 Source/Isotype: Rabbit IgG