CST, 19766S, Ferrostatin-1

Chemical Modulators for studying in the research area. Product Usage Information Ferrostatin-1 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.27 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect. Storage Store lyophilized at ambient temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. Background Ferrostatin-1 is an antioxidant that is a potent, selective inhibitor of erastin-induced ferroptosis with an EC value of 60 nM (1,2). It effectively inhibits ferroptosis in cancer cells and prevents glutamate-induced cell death in rat hippocampal brain slices. In disease models, it has been shown to inhibit production of reactive oxygen species (ROS) and depletion of membrane lipids (1). Ferrostatin-1 has been shown to inhibit cell death in cell models of Huntington's disease, periventricular leukomalacia, and kidney dysfunction (1,2). Alternate Names Ethyl 3-amino-4-(cyclohexylamino)benzoate