CST, 19771T, CX3CR1 (E9J4I) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CX3CR1. Validated for Flow Cytometry (Live). Available in 2 sizes. Highly specific and rigorously validated in-house, CX3CR1 (E9J4I) Rabbit Monoclonal Antibody (CST #19771) is ready to ship. Product Usage Information Flow Cytometry (Live): 1:50 - 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Flow Cytometry (Live) Specificity / Sensitivity CX3CR1 (E9J4I) Rabbit Monoclonal Antibody recognizes endogenous levels of total CX3CR1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CX3CR1 protein. Background CX3C chemokine receptor 1 (CX3CR1) is a member of the seven-transmembrane G-protein coupled receptor (GPCR) family. It is a receptor for its sole ligand, CX3CL1, also known as fractalkine or neurotactin (1). Immune cells that express CX3CR1 include monocytes, macrophages, microglia, T helper (Th) 1 cells, CD8 T effector/memory cells, NK cells, γδ T cells, and dendritic cells (DCs) (1,2). CX3CR1 has been implicated in inflammatory diseases, such as nephropathy and macular degeneration, and HIV co-receptors. It is emerging as an important player in the regulation of insulin secretion and beta cell function (3). In the brain, CX3CR1 expression is microglia-specific and regulates microglial recruitment to sites of neuroinflammation (1,2). Disruption of CX3CL1-CX3CR1 signaling promotes neurodegeneration in mouse models of Parkinson's disease and amyotrophic lateral sclerosis but might be protective in Alzheimer's disease (AD) (2,4,5). Alternate Names Beta chemokine receptor-like 1; C-X-X-X-C Chemokine Receptor 1; C-X3-C CKR-1; C-X3-C motif chemokine receptor 1; CCRL1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CMK-BRL-1; CMK-BRL1; CMKBRL1; CMKDR1; CX3C chemokine receptor 1; CX3C1; CX3CR1; Fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; GPR13; GPRV28; V28 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG