CST, 2094S, Rab7 Antibody

Polyclonal Antibody for studying Rab7. Validated for Western Blotting. Highly specific and rigorously validated in-house, Rab7 Antibody (CST #2094) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Rab7 Antibody detects endogenous levels of total Rab7 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding residue surrounding Asp193 of human Rab7. Antibodies are purified by peptide affinity chromatography. Background Rab7 and Rab9 are members of the Ras superfamily of small Rab GTPases (1). Both proteins are located in late endosomes, but exert different functions. Rab7 associates with the RIPL effector protein to control membrane trafficking from early to late endosomes and to lysosomes (2,3). Rab7 also helps to regulate growth receptor endocytic trafficking and degradation (3,4), and maturation of phagosome and autophagic vacuoles (4-6). Rab9 interacts with its effector proteins p40 and TIP47 (7,8) to promote the MPR (mannose 6-phosphate receptor)-associated lysosomal enzyme transport between late endosomes and the trans Golgi network (9,10). Alternate Names CMT2B; FLJ20819; PRO2706; RAB7; RAB7, member RAS oncogene family; RAB7A; RAB7A, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein Rab-7a Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 23 SOURCE: Rabbit