CST, 2192S, Presenilin 2 Antibody

Polyclonal Antibody for studying Presenilin-2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, Presenilin 2 Antibody (CST #2192) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Presenilin 2 Antibody detects endogenous levels of the carboxy-terminal fragment of presenilin 2 (23 kDa) and the full length protein (54 kDa) to a lesser extent. This antibody does not cross-react with endogenous levels of presenilin 1. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding amino acid 330 of human presenilin 2. Antibodies are purified by protein A and peptide affinity chromatography. Background Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated γ-secretase activity for amyloid-β protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3). Alternate Names AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; Alzheimer's disease 3-like; CMD1V; E5-1; presenilin 2; presenilin 2 (Alzheimer disease 4); Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS-2; PS2; PSEN2; PSN2; PSNL2; STM-2; STM2 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 23 (C-terminal fragment). 54 (full-length). SOURCE: Rabbit