CST, 2292S, NUP98 (P671) Antibody

Polyclonal Antibody for studying NUP98. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, NUP98 (P671) Antibody (CST #2292) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:25 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity NUP98 (P671) Antibody recognizes endogenous levels of NUP98 protein. Species Reactivity: Human, Mouse, Rat, Monkey, Bovine Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro671 of human NUP98. Antibodies are purified by protein A and peptide affinity chromatography. Background Nucleoporin 98 kDa (NUP98) is a component of the nuclear pore complex. It is expressed as three different precursors that undergo auto-cleavage to generate a common amino-terminal 98 kDa peptide (NUP98) and carboxy-terminal 6, 96 (NUP96) and 88 (p88) kDa peptides (1,2). NUP98 contains FG and GLFG repeat domains at its amino terminus and a RNA-binding domain in its carboxy terminus (3). The NUP98 gene is localized on chromosome 11p15.5, a region frequently rearranged in leukemias. To date, 15 fusion partners have been identified for NUP98 (4,5). Alternate Names 96 kDa nucleoporin; 98 kDa nucleoporin; ADAR2; ADIR2; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96; Nuclear pore complex protein Nup98; Nuclear pore complex protein Nup98-Nup96; nucleoporin 96; nucleoporin 98 and 96 precursor; nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup96; Nucleoporin Nup98; NUP196; NUP96; NUP98; Nup98-96; Nup98-Nup96; NUP98/PHF23 fusion 2 protein Specification REACTIVITY: H M R Mk B SENSITIVITY: Endogenous MW (kDa): 98 SOURCE: Rabbit