CST, 24696S, UPK3B (DBRRM3.66) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying UPK3B. Validated for Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, UPK3B (DBRRM3.66) Rabbit Monoclonal Antibody (CST #24696) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:800 - 1:3200 Storage Supplied in a PBS-based buffer containing sodium azide as a preservative. Stable for 12 months when stored at 4°C. Do not aliquot the antibody. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity UPK3B (DBRRM3.66) Rabbit Monoclonal Antibody recognizes endogenous levels of total UPK3B protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant human UPK3B protein. Background Uroplakins are a family of apical transmembrane proteins that form specialized plaques localized to the asymmetrical unit membrane (AUM), providing a permeability barrier in the urothelium (1). Urothelial plaques are composed of Uroplakin IIIB/UPK3B and at least four other uroplakins (UPK1A, UPK1B, UPK2, and UPK3) (2). UPK3B is expressed in urothelial carcinomas and other human cancers and has been shown to be useful as a biomarker in mesotheliomas (3,4). Alternate Names FLJ32198; MGC10902; p35; UP3b; UPIIIb; UPK3B; uroplakin 3B; Uroplakin IIIb; Uroplakin-3b Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: IgG