CST, 25289SF, LAIR-1 (E7X6I) Rabbit Monoclonal Antibody (BSA and Azide Free)

Monoclonal Antibody for studying LAIR-1. Validated for WB,IHC,IHC,IF,F. Highly specific and rigorously validated in-house, LAIR-1 (E7X6I) Rabbit Monoclonal Antibody (BSA and Azide Free) (CST #25289) is ready to ship. Product Usage Information This product is the carrier free version of product #60061. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol. This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us . Optimal dilutions/concentrations should be determined by the end user. BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity. Formulation Supplied in 1X PBS (10 mM Na 2 HPO 4 , 3 mM KCl, 2 mM KH 2 PO 4 , and 140 mM NaCl (pH 7.8)). BSA and Azide Free. For standard formulation of this product see product # 60061 Storage Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance. Specificity / Sensitivity LAIR-1 (E7X6I) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of total LAIR-1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LAIR-1 protein. Background LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation (1). LAIR1 has been noted to be upregulated in renal cell carcinoma (2), and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue (3). Alternate Names CD305; hLAIR1; immunoglobulin heavy chain variable region; LAIR-1; LAIR1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; Leukocyte-associated immunoglobulin-like receptor 1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 50 Source/Isotype: Rabbit IgG