CST, 25498S, LACTB Antibody

Polyclonal Antibody for studying LACTB. Validated for Western Blotting. Highly specific and rigorously validated in-house, LACTB Antibody (CST #25498) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity LACTB Antibody recognizes endogenous levels of total LACTB protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LACTB protein. Antibodies are purified by protein A and peptide affinity chromatography. Background LACTB is a serine beta-lactamase-like protein that is most prominently expressed in skeletal muscle, heart and liver (1). It contains an amino-terminal transmembrane domain and is localized to the mitochondrial intermembrane space, where it is polymerized into stable filaments that promote intramitochondrial membrane organization and micro-compartmentalization (2). Studies in multiple breast cancer cell types have shown that LACTB can function as a tumor suppressor by promoting decreased levels of phosphatidylserine decarboxylase (PISD), leading to reduced cell proliferation (3). In accordance with this, levels of LACTB have been shown to be downregulated in hepatocellular carcinoma and colorectal cancer and associated with poor prognosis in both (4,5). Alternate Names FLJ14902; G24; lactamase beta; lactamase, beta; LACTB; mitochondrial 39S ribosomal protein L56; mitochondrial ribosomal protein L56; MRPL56; serine beta lactamase-like protein LACTB; Serine beta-lactamase-like protein LACTB, mitochondrial; serine beta-lactamase-like protein, mitochondrial Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 54 SOURCE: Rabbit