CST, 26402T, FcRL3 (E1V4L) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying FcRL3. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, FcRL3 (E1V4L) Rabbit Monoclonal Antibody (CST #26402) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity FcRL3 (E1V4L) Rabbit Monoclonal Antibody recognizes endogenous levels of total FcRL3 protein. This antibody detects a 42 kDa band of unknown origin in some cell lines. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp70 of human FcRL3 protein. Background FcRL3 (Fc receptor-like protein 3, IRTA3, FcRH3) is a member of the Fc receptor-like family of proteins, which show high structural homology to classical Fc receptors in their extracellular domains (1,2). FcRL3 is a type I transmembrane protein, containing a long cytoplasmic tail with one ITAM, one ITIM, and an ITAM-like region (1,2). FcRL3 is primarily expressed in B lymphocytes in lymph nodes and germinal centers, although it has also been found in NK cells and subsets of T cells (1-6). Functional variants of the gene have been associated with autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), autoimmune thyroiditis, and autoimmune pancreatitis (3-6). FcRL3 has inhibitory potential on BCR-mediated signaling, possibly through the association of ITIMs with phosphatases SHIP, SHP-1, and SHP-2 (4). Alternate Names CD307c; Fc receptor homolog 3; Fc receptor like 3; Fc receptor-like 3; Fc receptor-like protein 3; FcR-like protein 3; FCRH3; FCRL3; hIFGP3; IFGP family protein 3; IFGP3; Immune receptor translocation-associated protein 3; immunoglobulin superfamily receptor translocation associated protein 3; IRTA3; SH2 domain-containing phosphatase anchor protein 2; SPAP2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 100, 120 Source/Isotype: Rabbit IgG