CST, 27144S, PVR/CD155 (F2S3T) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PVR mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, PVR/CD155 (F2S3T) Rabbit Monoclonal Antibody (CST #27144) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:100 - 1:400 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity PVR/CD155 (F2S3T) Rabbit Monoclonal Antibody recognizes endogenous levels of total PVR/CD155 protein. Species Reactivity: Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val190 of mouse PVR/CD155 protein. Background Poliovirus receptor (PVR), also known as CD155 and nectin-like 5 (Necl-5), is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells (1,2). Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells (3). Additional research indicates that PVR expression may play a role in the invasiveness of lung adenocarcinoma (4,5). In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity (6). Alternate Names 3830421F03Rik; CD155; D7Ertd458; D7Ertd458e; HVED; mE4; necl; necl-5; poliovirus receptor; Pvr; PVS; Taa1; Tage; Tage4; tumor-associated antigen 1; Tumor-associated glycoprotein E4 Specification REACTIVITY: M R SENSITIVITY: Endogenous MW (kDa): 70-100 Source/Isotype: Rabbit IgG