CST, 2763S, MESDC2 (C22F5) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MESD2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MESDC2 (C22F5) Rabbit Monoclonal Antibody (CST #2763) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MESDC2 (C22F5) Rabbit Monoclonal Antibody detects endogenous levels of total MESDC2 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a recombinant human MESDC2 protein. Background Mesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7 (1). MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6 (2). MESD is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling (3-5). The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass (6). Alternate Names BOCA; KIAA0081; LDLR chaperone MESD; LRP chaperone MESD; MESD; MESDC2; MESDM; Mesoderm development candidate 2; mesoderm development LRP chaperone; Mesoderm development LRP chaperone MESD; Mesoderm development protein; OI20; Renal carcinoma antigen NY-REN-61 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 25, 26 Source/Isotype: Rabbit IgG