CST, 28569T, MFSD1 (F2B4C) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MFSD1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MFSD1 (F2B4C) Rabbit Monoclonal Antibody (CST #28569) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity MFSD1 (F2B4C) Rabbit Monoclonal Antibody recognizes endogenous levels of total MFSD1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MFSD1 protein. Background Major facilitator superfamily domain-containing protein 1 (MFSD1) is a member of the solute carrier (SLC) superfamily that functions as a lysosomal dipeptide exporter (1-3). It forms a heterodimeric complex with glycosylated lysosomal membrane protein (GLMP) that functions as a critical accessory subunit for MFSD1 (3). Â knockout mice develop splenomegaly and severe liver disease, phenotypes that are mimicked in knockouts (4). In tumor models, loss of enables high levels of invasion and metastasis (5). MFSD1 is expressed in the TFEB gene network regulating lysosomal biogenesis and function (6). Alternate Names FLJ14153; major facilitator superfamily domain containing 1; Major facilitator superfamily domain-containing protein 1; MFSD1; Minerva; SMAP-4; SMAP4; Smooth muscle cell-associated protein 4 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 35 Source/Isotype: Rabbit IgG