CST, 2930S, Phospho-PSD93 (Tyr340) Antibody

Polyclonal Antibody for studying PSD-93 (Tyr340) phosphate. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, Phospho-PSD93 (Tyr340) Antibody (CST #2930) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Phospho-PSD93 (Tyr340) Antibody detects endogenous levels of PSD93 only when phosphorylated at Tyr340. Species Reactivity: Rat Source / Purification Antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr340 of human PSD93. Background Postsynaptic Density Protein 93 (PSD93) is a member of the PSD subfamily of the membrane-associated guanylate kinase (PSD-MAGUK) proteins. Structurally, it most closely resembles PSD95, consisting of an N-terminal variable segment followed by three PDZ domains, an SH3 domain, and an inactive guanylate kinase (GK) domain (1,2). PSD93 is expressed in neuronal cells and located at the synapse where it interacts with neuronal receptors and proteins including the NMDA receptor (2-4), K channels (5,6), and the AMPA receptor (7) to regulate their membrane localization and neuronal signaling. Research studies have implicated PSD93 in postsynaptic related persistent pain induction, making PSD93 a potential target for treatment of this syndrome (3). The phosphorylation site at Tyr340 of PSD93 was identified at Cell Signaling Technology (CST) using PhosphoScan , CST's MS/MS platform for phosphorylation site discovery. Phosphorylation of PSD93 at Tyr340 was observed in extracts isolated from reperfusion of ischemic rat brain. Alternate Names Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-110; discs large MAGUK scaffold protein 2; discs, large homolog 2 (Drosophila); discs, large homolog 2, chapsyn-110; Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; DLG2; FLJ37266; MGC131811; Postsynaptic density protein PSD-93; PPP1R58; protein phosphatase 1, regulatory subunit 58; PSD-93; PSD93 Specification REACTIVITY: R SENSITIVITY: Endogenous MW (kDa): 110 SOURCE: Rabbit