CST, 32790S, HMOX2/HO-2 (D9J9U) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying HMOX2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, HMOX2/HO-2 (D9J9U) Rabbit Monoclonal Antibody (CST #32790) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity HMOX2/HO-2 (D9J9U) Rabbit Monoclonal Antibody recognizes endogenous levels of total HMOX2/HO-2 protein. Species Reactivity: Human, Mouse, Rat, Hamster, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala131 of human HMOX2/HO-2 protein. Background Heme oxygenases (HMOX or HO) catalyze the rate-limiting step of the oxidative degradation of heme into iron, carbon monoxide, and biliverdin (1). Biliverdin is then converted to bilirubin (2). Heme is a strong pro-oxidant whereas bilirubin is a strong antioxidant (2). Research studies suggest disregulation of heme oxygenases may contribute to oxidative stress-related diseases (2). There are three isozymes of heme oxygenases: HMOX1/HO-1, HMOX2/HO-2, and HMOX3/HO-3 (1,2). HMOX1/HO-1 is inducible by heme and other stress stimuli (1,3). HMOX2/HO-2 and HMOX3/HO-3 are constitutively expressed (1,3). Alternate Names heme oxygenase (decycling) 2; Heme oxygenase 2; HMOX2; HO-2; HO2 Specification REACTIVITY: H M R Hm Mk SENSITIVITY: Endogenous MW (kDa): 36 Source/Isotype: Rabbit IgG