CST, 3290S, CD105/Endoglin Antibody

Polyclonal Antibody for studying CD105/endoglin mouse. Validated for Western Blotting. Highly specific and rigorously validated in-house, CD105/Endoglin Antibody (CST #3290) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CD105/Endoglin Antibody detects transfected levels of mouse CD105/Endoglin protein. Species Reactivity: Mouse Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro430 of mouse CD105/Endoglin. Antibodies are purified by peptide affinity chromatography. Background CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways (1,2). CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and endothelial and stromal cells. Upregulated CD105/Endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6). Alternate Names AI528660; AI662476; CD105; Cell surface MJ7/18 antigen; Edg; EGLN; Endo; Endoglin; Eng; OTTMUSP00000012838; S-endoglin; transmembrane glycoprotein Specification REACTIVITY: M SENSITIVITY: Transfected Only MW (kDa): 79, 81 SOURCE: Rabbit