CST, 33118S, TBXAS1 (F4C5I) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TBXAS1. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TBXAS1 (F4C5I) Rabbit Monoclonal Antibody (CST #33118) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity TBXAS1 (F4C5I) Rabbit Monoclonal Antibody recognizes endogenous levels of total TBXAS1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TBXAS1 protein. Background Thromboxane-A synthase (TBXAS1) converts prostaglandin H2 (PGH2) to thromboxane A2 (TXA2) in an isomerization reaction (1). Studies show that TXA2 regulates some cancer development processes, including cell growth, migration, and angiogenesis. In addition, TBXAS1 expression is upregulated in several cancers, suggesting its role in cancer progression and metastasis (2). Furthermore, senescent cells have increased levels of oxylipins. The levels of mRNA, which is involved in oxylipin biosynthesis, are also elevated in some senescent cells (3). Alternate Names BDPLT14; CYP5; CYP5A1; Cytochrome P450 5A1; cytochrome P450, family 5, subfamily A, polypeptide 1; FLJ52771; GHOSAL; platelet, cytochrome P450, subfamily V; TBXAS1; THAS; thromboxane A synthase 1; thromboxane A synthase 1 (platelet); Thromboxane-A synthase; TS; TXA synthase; TXAS; TXS Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 55 Source/Isotype: Rabbit IgG