CST, 33202T, MS4A4A (F2E6F) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MS4A4A. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MS4A4A (F2E6F) Rabbit Monoclonal Antibody (CST #33202) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity MS4A4A (F2E6F) Rabbit Monoclonal Antibody recognizes endogenous levels of total MS4A4A protein. A band of unknown origin is detected at 70 kDa by western blotting. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val130 of human MS4A4A protein. Background Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) is a member of a class of genes encoding four-transmembrane-spanning proteins (1,2). MS4A4A expression is enriched in human and mouse macrophages (3,4). Its expression in macrophages may be induced during macrophage development and activation (4). MS4A4A, via its interaction with the β-glucan receptor, Dectin-1, may contribute to macrophage-mediated production of proinflammatory cytokines and reactive oxygen species by activation of the Syk signaling pathway (4). Interestingly, MS4A4A, as well as other members of the gene cluster, is genetically linked to late-onset Alzheimer's disease, suggesting that MS4A4A-dependent macrophage/microglia might contribute to neurodegenerative disease progression (5,6). Alternate Names 4SPAN1; CD20 antigen-like 1; CD20-L1; CD20L1; epididymis secretory sperm binding protein; Fc epsilon receptor beta; Fc epsilon receptor beta subunit homolog; four-span transmembrane protein; Four-span transmembrane protein 1; HDCME31P; M4A4A; membrane spanning 4-domains A4A; Membrane-spanning 4-domains subfamily A member 4A; membrane-spanning 4-domains, subfamily A, member 4; membrane-spanning 4-domains, subfamily A, member 4A; MGC22311; MS4A4; MS4A4A; MS4A7; Q96JQ5 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 25 Source/Isotype: Rabbit IgG