CST, 33218S, Nicotinamide

Chemical Modulators for studying in the research area. Product Usage Information Nicotinamide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 2.73 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect. Storage Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. Background Nicotinamide, a form of vitamin B3, is a NAD+ precursor and inhibitor of sirtuin 1 (SIRT1) with an IC value of <50 uM (1). Nicotinamide is a key component of increasing cell survival and longevity, and plays a critical role in microglial function. It has been shown to prevent apoptosis in neuronal cells and is also a PARP-1 inhibitor, which has been shown to improve cognitive function in Alzheimer's disease patients (2). Alternate Names Niacinamide; Nicotinic acid amide; Pyridine-3-carboxylic acid amide; Vitamin B3