CST, 3432S, Cytokine Receptor Common beta-Chain Antibody

Polyclonal Antibody for studying CSF2RB. Validated for Western Blotting. Highly specific and rigorously validated in-house, Cytokine Receptor Common beta-Chain Antibody (CST #3432) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Cytokine Receptor Common beta-Chain Antibody detects endogenous levels of total cytokine receptor common beta-chain protein independent of phosphorylation. Species Reactivity: Human, Mouse, Rat, Monkey, Mink Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human cytokine receptor common beta-chain. Antibodies are purified by protein A and peptide affinity chromatography. Background The common beta-chain (beta-c) of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors is the major signaling subunit of these receptors, coupling ligand binding to multiple biological activities (1-3). Tyrosine phosphorylation of cytokine receptor common beta-chain is one of the first events in GM-CSF, IL-3, and IL-5 receptor activation and in signaling initiation. Serine phosphorylation within the 14-3-3 binding sequence of the common beta-chain is also involved in GM-CSF, IL-3, and IL-5 receptor-specific functions (4,5). Alternate Names beta common cytokine receptor; beta-GM-CSF receptor; betaGMR; CD131; CDw131; colony stimulating factor 2 receptor beta common subunit; colony stimulating factor 2 receptor subunit beta; colony stimulating factor 2 receptor, beta; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); colony-stimulating factor-2 receptor, beta, low-affinity; CSF2RB; Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; IL3RB; IL5RB; interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity); SMDP5 Specification REACTIVITY: H M R Mk Mi SENSITIVITY: Endogenous MW (kDa): 100 SOURCE: Rabbit