CST, 34367S, LYPLAL1 (F3Z9O) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LYPLAL1. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, LYPLAL1 (F3Z9O) Rabbit Monoclonal Antibody (CST #34367) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity LYPLAL1 (F3Z9O) Rabbit Monoclonal Antibody recognizes endogenous levels of total LYPLAL1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly72 of human LYPLAL1 protein. Background Lysophospholipase-like 1 (LYPLAL1) is a serine hydrolase that has been linked to various metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease (1,2). Although it is evolutionarily conserved, knockout studies in mice confirm that LYPLAL1 is not essential for normal metabolic function (3). LYPLAL1 has also been shown to depalmitoylate cyclic GMP-AMP synthase (cGAS), inhibiting cGAS enzymatic activity and downstream signaling (4). Inhibition of LYPLAL1 results in enhanced cGAS-mediated innate immune signaling, suggesting that this treatment could be used to bolster anti-tumor immunotherapies such as PD-1 blockade (4). Alternate Names FLJ99730; KIAA1238; LYPL1; LYPLAL1; lysophospholipase like 1; lysophospholipase-like 1; Lysophospholipase-like protein 1; Q96AV0 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 26 Source/Isotype: Rabbit IgG