CST, 34557S, CMTM6 Antibody

Polyclonal Antibody for studying CMTM6. Validated for Western Blotting. Highly specific and rigorously validated in-house, CMTM6 Antibody (CST #34557) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CMTM6 Antibody recognizes endogenous levels of total CMTM6 protein. This antibody does not cross-react with CMTM4 protein. Species Reactivity: Human, Mouse Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala176 of human CMTM6 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is a member of the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (1). CMTM6 stabilizes plasma membrane expression of PD-L1, an immune inhibitory ligand critical for immune tolerance to self and anti-tumor immunity (2,3). CMTM6 associates with PD-L1 at recycling endosomes, where it protects PD-L1 from being targeted for lysosomal degradation by preventing STUB1-mediated PD-L1 ubiquitination (2,3). CMTM6 may stabilize PD-L1 expression on antigen presenting cells and potentiate inhibitory signaling by PD-1 on T cells, triggering T cell inhibition and exhaustion. CMTM6 has also been shown to interact with CD58, ARG1, ENO1, and TMPO (2). Due to the role of CMTM6 in regulating the immune system, it is being investigated as an immunotherapeutic target for the treatment of cancer. Alternate Names chemokine-like factor super family 6; chemokine-like factor superfamily 6; Chemokine-like factor superfamily member 6; CKLF like MARVEL transmembrane domain containing 6; CKLF-like MARVEL transmembrane domain containing 6; CKLF-like MARVEL transmembrane domain-containing protein 6; CKLF6; CKLFSF6; CMTM6; FLJ20396; PRO2219 Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 22 SOURCE: Rabbit