CST, 3526S, RalA Antibody

Polyclonal Antibody for studying RalA. Validated for Western Blotting. Highly specific and rigorously validated in-house, RalA Antibody (CST #3526) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity RalA Antibody detects endogenous levels of total human RalA protein. Species Reactivity: Human, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala142 of human RalA. Antibodies are purified by peptide affinity chromatography. Background RalA and RalB are members of the Ras family of small GTPases and are highly homologous in protein sequence. The functions of RalA and RalB are distinct yet overlapping. By binding to various effector proteins, RalA and RalB serve as important GTP sensors for exocytosis and membrane trafficking (1-3). RalA is required for Ras-related tumorigenesis (4) and RalB is important for tumor survival (5). In addition to tumor formation, Ral proteins also play a role in cancer cell migration and metastatic tumor invasion (6,7). Alternate Names MGC48949; RAL; RALA; RALA Ras like proto-oncogene A; Ras family small GTP binding protein RALA; RAS like proto-oncogene A; ras related GTP binding protein A; ras related v-ral simian leukemia viral oncogene homolog A; RAS-like protein A; Ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related) Specification REACTIVITY: H Mk SENSITIVITY: Endogenous MW (kDa): 25 SOURCE: Rabbit