CST, 35371T, HSD17B13 (E5K7Q) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying HSD17B13. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, HSD17B13 (E5K7Q) Rabbit Monoclonal Antibody (CST #35371) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity HSD17B13 (E5K7Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total HSD17B13 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser103 of human HSD17B13 protein. Background HSD17B13, also known as hydroxysteroid 17-beta dehydrogenase 13, is a liver-enriched, hepatocyte-specific, lipid droplet-associated protein involved in the metabolism of steroid hormones (1). HSD17B13 has been linked to the development of non-alcoholic fatty liver disease (NAFLD), a condition characterized by the accumulation of fat in the liver that can lead to liver damage and inflammation (2). Hepatic expression of HSD17B13 is significantly upregulated in NAFLD patients relative to healthy individuals, with expression levels correlating with disease severity (3,4). Moreover, several loss-of-function variants in are associated with a reduced risk of chronic liver disease and decreased disease severity of NAFLD (5,6). These findings suggest that HSD17B13 may be a potential therapeutic target for the treatment of liver fibrosis and NAFLD. Alternate Names 17-beta hydroxysteroid dehydrogenase; 17-beta-HSD 13; 17-beta-hydroxysteroid dehydrogenase 13; DHB13; HMFN0376; HSD17B13; hydroxysteroid (17-beta) dehydrogenase 13; hydroxysteroid 17-beta dehydrogenase 13; MGC138508; MGC138510; NIIL497; SCDR9; SDR16C3; Short chain dehydrogenase/reductase family 16C member 3; short chain dehydrogenase/reductase family 16C, member 3; Short-chain dehydrogenase/reductase 9 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 30 Source/Isotype: Rabbit IgG