CST, 35909S, IFI35 (E3A8S) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Ifi35. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, IFI35 (E3A8S) Rabbit Monoclonal Antibody (CST #35909) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity IFI35 (E3A8S) Rabbit Monoclonal Antibody recognizes endogenous levels of total IFI35 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val250 of human IFI35 protein. Background Interferon-induced 35 kDa protein (IFI35) is a leucine zipper-containing protein that is upregulated in response to type I and type II interferons (1,2). Research studies have demonstrated that intracellular pools of IFI35, in complex with NMI, negatively regulate innate immune antiviral signaling by blunting type I interferon production (3,4). Extracellularly, IFI35 has been shown to modulate the innate immune response by functioning as a proinflammatory damage-associated molecular pattern (DAMP) upon release by activated macrophages (5,6). Alternate Names FLJ21753; Ifi-35; IFI35; IFP 35; IFP35; IN35; interferon induced protein 35; Interferon-induced 35 kDa protein; interferon-induced protein 35 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 32 Source/Isotype: Rabbit IgG