CST, 36845T, OASL (E7W1R) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying OASL. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, OASL (E7W1R) Rabbit Monoclonal Antibody (CST #36845) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity OASL (E7W1R) Rabbit Monoclonal Antibody recognizes endogenous levels of total OASL protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys504 of human OASL protein. Background The 2'-5'-oligoadenylate synthetase (OAS) family of interferon-induced proteins plays an important role in cellular innate immune response (1-4). When activated by double-stranded RNA, these proteins polymerize ATP into 2′-5′-linked oligomers (2,3,5). These 2'-5'-linked oligoadenylates bind to the ribonuclease RNase L, degrading viral and cellular RNA (2,3,5). In humans, the OAS family of proteins includes OAS1, OAS2, OAS3, and OASL (1-3). OASL differs from the other OAS family members in that it lacks 2'-5' oligoadenylate synthase activity, but can bind double-stranded RNA (6). Recent studies have shown that OASL shows antiviral activity via an alternative antiviral pathway independent of RNase L (7). Alternate Names 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 2'-5'-oligoadenylate synthase-like protein; 2'-5'-oligoadenylate synthetase like; 2'-5'-oligoadenylate synthetase-like; 59 kDa 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; OASL; OASL1; OASLd; p59 OASL; p59-OASL; p59OASL; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; TRIP14 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 52 Source/Isotype: Rabbit IgG