CST, 37849S, MX1 (D3W7I) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MX1. Validated for WB,IP,IHC,IHC. Available in 2 sizes. Highly specific and rigorously validated in-house, MX1 (D3W7I) Rabbit Monoclonal Antibody (CST #37849) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 IHC Leica Bond: 1:100 - 1:400 Immunohistochemistry (Paraffin): 1:100 - 1:400 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 62815 . Protocol Available protocols: Western Blotting, Immunoprecipitation, IHC Leica Bond, Immunohistochemistry (Paraffin) Specificity / Sensitivity MX1 (D3W7I) Rabbit Monoclonal Antibody recognizes endogenous levels of total MX1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu292 of human MX1 protein. Background MX1 (Myxovirus resistance protein 1/MxA) is an interferon-inducible antiviral protein that confers resistance to RNA viruses (1-4). MX1 has GTPase activity, and GTP-bound MX1 adopts a conformation that enables interaction with viral nucleocapsids (5-7). This interaction blocks transport of viral nucleocapsids to the nucleus, which prevents transcription of the viral genome (7,8). Structural studies suggest that the antiviral activity of MX1 involves the formation of MX1 oligomeric rings around viral nucleocapsids (9-12). Alternate Names IFI-78K; IFI78; interferon inducible protein p78; Interferon-induced GTP-binding protein Mx1; Interferon-induced GTP-binding protein Mx1, N-terminally processed; Interferon-induced protein p78; interferon-inducible protein p78; Interferon-regulated resistance GTP-binding protein MxA; lncMX1-215; MX; MX dynamin like GTPase 1; MX1; MxA; Myxoma resistance protein 1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse); Myxovirus resistance protein 1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 76 Source/Isotype: Rabbit IgG