CST, 37908S, SERPINB9 (E9J8J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SERPINB9. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, SERPINB9 (E9J8J) Rabbit Monoclonal Antibody (CST #37908) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:200 - 1:800 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 51560 . Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity SERPINB9 (E9J8J) Rabbit Monoclonal Antibody recognizes endogenous levels of total SERPINB9 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with human SERPINB9 recombinant protein and reacts with an epitope surrounding Phe70. Background SERPINB9 (Sb9, PI-9) is a member of the serpin superfamily of proteins which bind to and inactivate serine proteinases (1,2). SERPINB9 is present in human CD4 T cells, CD8 T cells, NK cells, B cells, and myeloid cells, and is a physiological inhibitor of Granzyme B (GrB) (1,3,4). Granzyme B triggers apoptosis when released by cytotoxic T lymphocytes (1-4). SERPINB9 may function to protect effector and bystander cells from Granzyme B during an immune response (4). In mice, SPI6 is thought to be the functional homolog of SERPINB9 due to its inhibition of murine Granzyme B (2,5). SERPINB9 was recently identified as a potential immunotherapy target, due to its role in tumor cell survival through evasion of apoptosis (6). Alternate Names CAP-3; CAP3; Cytoplasmic antiproteinase 3; Peptidase inhibitor 9; PI-9; PI9; protease inhibitor 9 (ovalbumin type); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; Serpin B9; serpin family B member 9; serpin peptidase inhibitor, clade B (ovalbumin), member 9; serpin peptidase inhibitor, clade B, member 9; SERPINB9; SPB9; testicular tissue protein Li 180 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 42 Source/Isotype: Rabbit IgG