CST, 3801S, MMP-7 (D4H5) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MMP7 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, MMP-7 (D4H5) Rabbit Monoclonal Antibody (CST #3801) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 50116 . Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity MMP-7 (D4H5) Rabbit Monoclonal Antibody detects endogenous levels of total MMP-7 protein. Species Reactivity: Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile264 of mouse MMP-7 protein. Background The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis (2-4). Research studies have shown that MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full-length protein (5). Alternate Names MAT; Matrilysin; matrilysin, uterine; Matrin; matrix metallopeptidase 7; matrix metalloproteinase 7; Matrix metalloproteinase-7; MMP-7; Mmp7; Pump-1 protease; Uterine metalloproteinase Specification REACTIVITY: M R SENSITIVITY: Endogenous MW (kDa): 28, 20-22 Source/Isotype: Rabbit