CST, 39070S, LARG (E4I3L) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LARG. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, LARG (E4I3L) Rabbit Monoclonal Antibody (CST #39070) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity LARG (E4I3L) Rabbit Monoclonal Antibody recognizes endogenous levels of total LARG protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human LARG protein. Background The leukemia-associated Rho guanine nucleotide exchange factor (LARG, also known as ARHGEF12) was originally identified as a novel fusion partner of the mixed-lineage leukemia protein in an acute myeloid leukemia patient. LARG activates RhoA and RhoC but not Rac1 or Cdc42. (1,2). It has been shown to play a role in glioblastoma cell invasion and resistance (2). Furthermore, LARG is associated with certain forms of synaptic plasticity, where, as a binding partner of GluD1, it plays a role in inhibitory synapse formation (3). Alternate Names ARHGC; ARHGEF12; DKFZp686O2372; KIAA0382; LARG; leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; PRO2792; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 220 Source/Isotype: Rabbit IgG