CST, 39379T, IL-1R1 (F6I2P) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying IL1R1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, IL-1R1 (F6I2P) Rabbit Monoclonal Antibody (CST #39379) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity IL-1R1 (F6I2P) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-1R1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human IL-1R1 protein. Background Interleukin-1 receptor type 1 (IL-1R1) is a transmembrane protein in the interleukin-1 (IL-1) protein family (1-3). IL-1R1 is the receptor for IL-1, which plays a central role in inflammatory responses (1-3). The IL-1 signaling cascade is initiated by the binding of interleukin-1 alpha (IL-1α) or interleukin-1 beta (IL-1β) to IL-1R1, which recruits the IL-1 receptor accessory protein (IL-1RAP) to form a receptor complex, leading to downstream expression of proinflammatory cytokines and chemokines (1-4). The IL-1 receptor antagonist (IL-1Ra) competes with IL-1α and IL-1β to bind IL-1R1, acting as an inhibitor of the IL-1 signaling pathway (4). Aberrant activation of the IL-1 pathway is associated with multiple disorders, such as rheumatoid arthritis, degenerative diseases, cardiovascular disorders, and cancer (4). Alternate Names antigen CD121a; CD121 antigen-like family member A; CD121A; D2S1473; IL-1R-1; IL-1R-alpha; IL-1RA; IL-1RT-1; IL-1RT1; IL1R; IL1R1; IL1RA; IL1RT1; interleukin 1 receptor alpha, type I; interleukin 1 receptor type 1; interleukin 1 receptor, type I; interleukin receptor 1; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type 1, membrane form; Interleukin-1 receptor type 1, soluble form; Interleukin-1 receptor type I; mIL-1R1; mIL-1RI; p80; sIL-1R1; sIL-1RI Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 70-90 Source/Isotype: Rabbit IgG