CST, 39418S, RTP4 (F7F6V) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying RTP4. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, RTP4 (F7F6V) Rabbit Monoclonal Antibody (CST #39418) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity RTP4 (F7F6V) Rabbit Monoclonal Antibody recognizes endogenous levels of total RTP4 protein. This antibody detects a 55 kDa and an 80 kDa protein of unknown identity in some cell lines. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile190 of human RTP4 protein. Background Receptor-transporting protein 4 (RTP4) is a member of the RTP family of receptor chaperone proteins (1-3). The RTP family targets class A G protein-coupled receptors (GPCRs), which can act as receptors for taste, odor, and opioids (1-3). RTP4 mediates the maturation and trafficking of a heteromer consisting of a μ-opioid receptor (MOR) and δ-opioid receptor (DOR) and affects pain perception (1,3). As part of the immune response, RTP4 may contribute to the suppression of type I IFN induction during the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway following pathogen infection, functioning as a negative regulator (1,6). Additionally, human RTP4 binds to viral RNA and targets the replication phase of viral infection in testing coronavirus family members, including SARS-CoV-2, and is associated with the reduction of nucleocapsid protein (5). Alternate Names 28 kDa interferon-responsive protein; 28kD interferon responsive protein; 3CxxC-type zinc finger protein 4; IFRG28; receptor (chemosensory) transporter protein 4; receptor transporter protein 4; receptor transporting protein 4; Receptor-transporting protein 4; RTP4; Z3CXXC4; zinc finger, 3CxxC-type 4 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 28 Source/Isotype: Rabbit IgG