CST, 39447T, Neogenin (D7M8E) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Neogenin. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Neogenin (D7M8E) Rabbit Monoclonal Antibody (CST #39447) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Neogenin (D7M8E) Rabbit Monoclonal Antibody recognizes endogenous levels of total neogenin protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile1250 of human neogenin protein. Background Neogenin is a member of the Deleted in Colorectal Cancer (DCC) receptor family. It acts as an attractive axon guidance receptor in response to netrin, and as a repellent receptor when interacting with RGMa (1,2). Neogenin also regulates adhesion and tissue organization, such as bone formation, mammary gland morphogenesis, and skeletal myofiber development, by interacting with secreted netrins (3-5). In addition, neogenin is a key regulator of adult neurogenesis by synchronizing neuroblast migration and differentiation (6). Neogenin expression has been found to be associated with cellular phenotype in cancer. In breast cancer, neogenin expression is inversely correlated with cancer grade (7), while in gastric cancer, up regulation of neogenin was found to increase cell proliferation and motility (8). Alternate Names DKFZp547A066; DKFZp547B146; IGDCC2; Immunoglobulin superfamily DCC subclass member 2; NEO1; Neogenin; neogenin 1; neogenin homolog 1; neogenin homolog 1 (chicken); NGN; NTN1R2 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 210 Source/Isotype: Rabbit IgG