CST, 39784T, PLZF (D8G3G) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PLZF. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, PLZF (D8G3G) Rabbit Monoclonal Antibody (CST #39784) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:50 - 1:250 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity PLZF (D8G3G) Rabbit Monoclonal Antibody recognizes endogenous levels of total PLZF protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val248 of human PLZF protein. Background PLZF (promyelocytic leukemia zinc finger), is a transcriptional repressor and an epigenetic regulator. It belongs to a large family of BTB-POZ domain containing transcriptional repressors (1). It was first discovered as a fusion partner of RAR (Retinoic Acid Receptor) in the chromosomal translocation t(11; 17) in a case of in acute promyelocytic leukemia (2). PLZF is thought to regulate hematopoietic stem cell quiescence (3,4), maintain spermatogenesis (5), and direct differentiation of distinct populations of natural killer cells (6-9). Alternate Names PLZF; promyelocytic leukaemia zinc finger; Promyelocytic leukemia zinc finger protein; ZBT16; ZBTB16; zinc finger and BTB domain containing 16; Zinc finger and BTB domain-containing protein 16; Zinc finger protein 145; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); Zinc finger protein PLZF; ZNF145 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 80 Source/Isotype: Rabbit IgG