CST, 4102S, ROR1 Antibody

Polyclonal Antibody for studying ROR1. Validated for Western Blotting. Highly specific and rigorously validated in-house, ROR1 Antibody (CST #4102) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity ROR1 Antibody detects transfected levels of ROR1 proteins. This antibody does not cross-react with ROR2. Species Reactivity: Mouse Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the residues surrounding Pro87 of human ROR1 protein. The antibodies are purified by protein A and peptide affinity chromatography. Background ROR1 and ROR2 are orphan receptor tyrosine kinases that are most closely related to MuSK and the Trk family of neurotrophin receptors. They are characterized by the presence of extracellular frizzled-like cysteine-rich domains and membrane-proximal kringle domains, both of which are assumed to mediate protein-protein interactions (1-3). The ROR family RTKs are evolutionarily conserved among , , mice, and humans (1,4). Although the functions of ROR kinases are unknown, similarities between ROR and MuSK and Trk kinases have led to speculation that ROR kinases regulate synaptic development. CAM-1, a ortholog of the ROR family RTKs, plays several important roles in regulating cellular migration, polarity of asymmetric cell divisions, and axonal outgrowth of neurons during nematode development (4). mROR1 and mROR2 may play differential roles during the development of the nervous system (5). Alternate Names dJ537F10.1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; neurotrophic tyrosine kinase receptor-related 1; Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1; receptor tyrosine kinase like orphan receptor 1; receptor tyrosine kinase-like orphan receptor 1; ROR1; Tyrosine-protein kinase transmembrane receptor ROR1 Specification REACTIVITY: M SENSITIVITY: Transfected Only MW (kDa): 135 SOURCE: Rabbit