CST, 41033S, CD84 Antibody

Polyclonal Antibody for studying CD84 mouse. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, CD84 Antibody (CST #41033) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity CD84 Antibody recognizes endogenous levels of total CD84 protein. This antibody cross-reacts with an unidentified protein of 17 kDa. Species Reactivity: Mouse Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala322 of mouse CD84 protein. Antibodies are purified by peptide affinity chromatography. Background Cluster of Differentiation 84 (CD84), also known as signaling lymphocytic activation molecule family member 5 (SLAMF5), is a membrane glycoprotein expressed by numerous immune cell types, including hematopoietic progenitor cells, T cells, B cells, NK cells, macrophages, monocytes, dendritic cells, platelets, mast cells, and thymocytes (1-9). CD84 is a homophilic adhesion molecule involved in modulating the activation, differentiation, proliferation, and cytotoxicity of a wide variety of immune cells, and thus is involved in the regulation and interconnection of both the innate and adaptive immune response (6-14). Certain CD84 activities are regulated by the presence or absence of small cytoplasmic adaptor proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (5,14). Alternate splicing results in multiple transcript variants. Alternate Names A130013D22Rik; Cd84; CD84 antigen; CDw84; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; SLA; SLAF5; SLAM family member 5; Slamf5 Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 45-80 SOURCE: Rabbit