CST, 41112S, MICAL1 (D8K7R) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MICAL1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MICAL1 (D8K7R) Rabbit Monoclonal Antibody (CST #41112) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MICAL1 (D8K7R) Rabbit Monoclonal Antibody recognizes endogenous levels of total MICAL1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val1038 of human MICAL1 protein. Background Molecule interacting with CasL protein 1 (MICAL1) is a Protein-methionine sulfoxide oxidase. MICAL1 can bind directly to F-actin and oxidize specific methionine residues to promote actin filament disassembly (1-3). MICAL1 is an important component of semaphorin signaling cascades that has effects on cell movement, angiogenesis, immunology, diabetes, and cancer (2,4-6). MICAL1 binds to NDR1/2 and antagonizes MST1-induced NDR activation and apoptosis (7). Alternate Names [F-actin]-methionine sulfoxide oxidase MICAL1; [F-actin]-monooxygenase MICAL1; CasL interacting molecule; DKFZp434B1517; FLJ11937; FLJ21739; MICA1; MICAL; MICAL-1; MICAL1; microtubule associated monooxygenase, calponin and LIM domain containing 1; microtubule associated monoxygenase, calponin and LIM domain containing 1; Molecule interacting with CasL protein 1; NEDD9 interacting protein with calponin homology and LIM domains; NEDD9-interacting protein with calponin homology and LIM domains; NICAL; protein-methionine sulfoxide oxidase MICAL1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 130 Source/Isotype: Rabbit IgG