CST, 41743S, PTGDS (F5R5O) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PTGDS. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, PTGDS (F5R5O) Rabbit Monoclonal Antibody (CST #41743) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity PTGDS (F5R5O) Rabbit Monoclonal Antibody recognizes endogenous levels of total PTGDS protein. Species Reactivity: Human, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val30 of human PTGDS protein. Background Prostaglandin D2 synthase (PTGDS), also known as lipocalin-type prostaglandin-D synthase (L-PGDS), catalyzes the conversion of prostaglandin H (PGH ) to prostaglandin D (PGD ) (1,2). Studies show that senescent cells have increased levels of oxylipins. The levels of mRNA, which is involved in oxylipin biosynthesis, are also elevated in some senescent cells (3). In addition, the gene encoding this enzyme in mice was identified as a genetic marker for temperature-sensitive neurons in the preoptic area of anterior hypothalamus (POA). This enzyme is critical for thermoregulation, and when the temperature rises in mouse POA, it generates more PGD in temperature-sensitive neurons, reducing core body temperature (2). Alternate Names Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; L-PGDS; lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; LPGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; prostaglandin D synthase; prostaglandin D2 synthase; prostaglandin D2 synthase 21kDa (brain); prostaglandin D2 synthase, brain; Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; PTGDS; testis tissue sperm-binding protein Li 63n Specification REACTIVITY: H R SENSITIVITY: Endogenous MW (kDa): 25 Source/Isotype: Rabbit IgG