CST, 41798T, Nectin-4/PVRL4 (E5Q1W) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Nectin 4. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Nectin-4/PVRL4 (E5Q1W) Rabbit Monoclonal Antibody (CST #41798) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Nectin-4/PVRL4 (E5Q1W) Rabbit Monoclonal Antibody recognizes endogenous levels of total Nectin-4/PVRL4 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr283 of human Nectin-4/PVRL4 protein. Background Nectin-4/poliovirus receptor-related 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions (1-3). The extracellular domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus (4) and to neighboring cells through heterophilic interactions with Nectin-1 (5,6). Unlike other nectin family members, which are widely expressed in adult tissues, Nectin-4 expression in humans is largely restricted to the placenta (7). Research studies have demonstrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas (8), breast (9,10), lung (11), and ovary (12). Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel diagnostic and therapeutic target for a variety of human tumors. Alternate Names EDSS1; Ig superfamily receptor LNIR; LNIR; NECT4; nectin 4; Nectin cell adhesion molecule 4; Nectin-4; NECTIN4; poliovirus receptor-related 4; Poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; PRR4; PVRL4 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 62, 75 Source/Isotype: Rabbit IgG